Clopidogrel and PPI use Consensus Report from the American College of Cardiology Foundation, the American College of Gastroenterology, and the American Heart Association

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Pick a Topic: Home New Postings Patient Postings Clinician Postings Join Our Email List Useful Web Links CE Opportunities Training Programs Guidelines DVT & PE Stories Editorial Board Financial Support About ClotCare DVT Coalition Contact Us Find info on a: Specific Medicine or Treatment Type of Medicine or Treatment Condition or Medical Procedure Lab Test Procedure Management Issue ClotCare complies with the HONcode standard for trustworthy health information: verify here. ClotCare is a member organization of the Coalition to Prevent Deep Vein Thrombosis. Click here to learn more about the Coalition to Prevent Deep Vein Thrombosis and DVT Awareness Month, which is held each March.	Clopidogrel and PPI use Consensus Report from the American College of Cardiology Foundation, the American College of Gastroenterology, and the American Heart Association Henry I. Bussey, Pharm.D. December, 2010 The Clopidogrel and PPI use Consensus Report from the American College of Cardiology Foundation, the American College of Gastroenterology, and the American Heart Association – 2010 is available online at content.onlinejacc.org/cgi/reprint/j.jacc.2010.09.010v1.pdf The controversial issue of combining omeprazole (and perhaps other proton pump inhibitors) with the antiplatelet agent clopidogrel (brand name Plavix) is reviewed and a consensus statement provided. The bottom line seems to be that PPI therapy is not needed if the patient does not have risk factors for gastrointestinal (GI) bleeding. The consensus report, however, does recommend a PPI for those at increased risk of bleeding, which would include individuals who have a prior history of GI bleeding, advanced age, concurrent anticoagulant and/or antiplatelet therapy (including aspirin and NSAIDs), or glucocorticoid therapy. Although a specific PPI is not recommended, the report does indicate that the strongest data for an interaction between a PPI and clopidogrel is with omeprazole. The potential merits of genetic testing, platelet function testing, and/or using an H2 blocker rather than a PPI are also discussed. Areas that deserve further research are identified and the reader is left with the impression that this statement may be updated as more information becomes available. How the new antiplatelet agents may fit into this discussion is not a major focus of this consensus report.	Have questions? Ask ClotCare. Send questions by email to webmaster@clotcare.org. ClotCare is a 501(c)(3) non-profit organization generously supported by your tax-deductible donations and grants from our industry supporters. New Postings: Click here to view full list of new postings
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Key topics discussed on ClotCare include: Blood Clots \| Deep Vein Thrombosis (DVT) \| Pulmonary Embolism (PE) \| Atrial Fibrillation (A. Fib or AF) \| Heart Attack \| Stroke \| Transient Ischemic Attack (TIA) \| Mini Stroke \| Bleeding Complications \| Vascular Surgery \| Surgical Blood Clot Removal \| Warfarin \| Coumadin \| Lovenox \| Low Molecular Weight Heparin (LMWH) \| Heparin \| Anticoagulants \| Plavix \| Aspirin \| Antiplatelets \| Blood Thinners
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