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Low Molecular Weight Heparin Use Following Prosthetic Valve Surgery Reduces Cost and Length of Stay
Ann K. Wittkowsky, Pharm.D., CACP
February, 2004
Review: Fanikos J, Tsilimingras K, Kucher N, Rosen A, Hieblinger M, Goldhaber S. Comparison of efficacy, safety, and cost of low-molecular-weight heparin with continuous-infusion unfractionated heparin for initiation of anticoagulation after mechanical prosthetic valve implantation. The American Journal of Cardiology 2004;93:247-250.
A recent study published in The American Journal of Cardiology is a retrospective cost analysis of post-operative anticoagulation in 63 patients undergoing valve replacement surgery. Compared to unfractionated heparin, post operative low molecular weight heparin therapy was associated with significantly lower post-operative costs, primarily attributed to reduced length of stay. No differences in clinical outcomes, including bleeding, thromboembolic events, or 90 day mortality, were observed.
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