ClotCare: Blood Clots, Stroke, Heart Attack
Friday, July 12, 2024
Home   |   DVT/PE   |   Blood Clots   |   Coumadin/Warfarin   |   New Patients   |   Self Testing   |   Email List   |   Donate

Pick a Topic:

Find info on a:

We subscribe to the HONcode principles of the HON Foundation. Click to verify.
ClotCare complies with the HONcode standard for trustworthy health
verify here.

ClotCare is a member of the Coalition to Prevent Deep Vein Thrombosis (DVT Coalition)  ClotCare is a member organization of the Coalition to Prevent Deep Vein Thrombosis. Click here to learn more about the Coalition to Prevent Deep Vein Thrombosis and DVT Awareness Month, which is held each March.

Rivaroxaban approved for stroke prevention in non-valvular atrial fibrillation

Henry I. Bussey, Pharm.D.
November, 2011

Rivaroxaban (brand name Xarelto), an oral anti-factor Xa (FXa) inhibitor, was approved on Nov. 4, 2011 for stroke prevention in individuals with non-valvular atrial fibrillation. The FDA report (
) indicates that the product information will contain a boxed warning advising individuals taking the drug to consult their health care professional before discontinuing the drug because of an increased risk of stroke following discontinuation of the drug. According to CardioSource, the FDA's Cardiovascular and Renal Drugs Advisory Committee recommended that rivaroxaban should only be offered as a third-line therapy (behind warfarin and dabigatran); but such a limitation was not addressed in the FDA approval announcement. In the ROCKET AF (atrial fibrillation) trial with rivaroxaban vs warfarin, there was no "signal" of an increased risk of myocardial infarction with rivaroxaban as was seen with dabigatran in the RE LY trial (and discussed on ClotCare at In addition, the issue of 30-day or 60-day product stability with dabigatran (also discussed on ClotCare at has not been an identified problem with rivaroxaban. It would seem, therefore, that choosing between either of the new agents (rivaroxaban or dabigatran) involves weighing product-specific limitations for each agent.

Ask a question about blood clots or anticoagulant medications Have questions? Ask ClotCare. Send questions by email to

ClotCare is a 501(c)(3) non-profit organization generously supported by your tax-deductible donations and grants from our industry supporters.

Blood Clot Activities Calendar

New Postings:

Click here to view full list of new postings
ClotCare Home | New Postings | Patient Postings | Clinician Postings | Join Our Email List | Useful Web Links
CE Opportunities | Training Programs | DVT & PE Stories | Editorial Board | Financial Support
About ClotCare | DVT Coalition | Donate to ClotCare | Contact Us
Key topics discussed on ClotCare include: Blood Clots | Deep Vein Thrombosis (DVT) | Pulmonary Embolism (PE) | Atrial Fibrillation (A. Fib or AF) | Heart Attack | Stroke | Transient Ischemic Attack (TIA) | Mini Stroke | Bleeding Complications | Vascular Surgery | Surgical Blood Clot Removal | Warfarin | Coumadin | Lovenox | Low Molecular Weight Heparin (LMWH) | Heparin | Anticoagulants | Plavix | Aspirin | Antiplatelets | Blood Thinners
Copyright 2000-2018 by ClotCare. All rights reserved.
Terms, Conditions, & Privacy | Image Copyright Information
19260 Stone Oak Parkway, Suite 101 | San Antonio, TX 78258 | 210-860-0487
Send comments to
Friday, July 12, 2024