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Exogenous Testosterone + Factor V Leiden = Increased Risk of Thrombosis?

Posted by Henry I. Bussey, Pharm.D.
February, 2012

Dr. Charles J. Glueck of the Jewish Hospital of Cincinnati, Ohio recently contacted ClotCare regarding a publication from his group in which testosterone supplementation in six men was followed by thromboembolism (2 developed bilateral osteonecrosis of the hip, 3 developed pulmonary embolism, and one developed amaurosis fugax).1 Five of the six were found to be heterozygous for Factor V Leiden and the other patient was a 70 year old male with elevated Factor VIII, Factor XI, and homocysteine. None of these patients had a prior history of – or risk factors for - thrombosis except that 3 had a family history of thrombosis. Dr. Glueck and colleagues suggest that the aromatization of testosterone to estradiol may have a synergistic prothrombotic effect in men with Factor V Leiden just as has been observed in women with Factor V Leiden who use hormonal contraceptives. Dr. Glueck has graciously volunteered to assist others who may wish to explore this potential interaction further. He can be reached at


Glueck CJ, Goldenberg N, Budhani S, et al. Thrombotic events after starting exogenous testosterone in men with previously undiagnosed familial thrombophilia. Translational Research 2011; 158:225-234 (doi: 10.1016/j.trsl.2011.06.003)

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Friday, July 12, 2024