Vitamin E Increases Risk of Hemorrhagic Stroke, Reduces Ischemic Stroke

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Friday, April 19, 2024

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Pick a Topic: Home New Postings Patient Postings Clinician Postings Join Our Email List Useful Web Links CE Opportunities Training Programs Guidelines DVT & PE Stories Editorial Board Financial Support About ClotCare DVT Coalition Contact Us Find info on a: Specific Medicine or Treatment Type of Medicine or Treatment Condition or Medical Procedure Lab Test Procedure Management Issue ClotCare complies with the HONcode standard for trustworthy health information: verify here. ClotCare is a member organization of the Coalition to Prevent Deep Vein Thrombosis. Click here to learn more about the Coalition to Prevent Deep Vein Thrombosis and DVT Awareness Month, which is held each March.	Vitamin E Increases Risk of Hemorrhagic Stroke, Reduces Ischemic Stroke Henry I. Bussey, Pharm.D. December, 2010 A large meta analysis of 9 placebo controlled trials including approximately 119,000 patients found that vitamin E supplementation increases the risk of hemorrhagic stroke by 20% while reducing ischemic stroke by 10%. It was estimated that vitamin E supplementation would prevent one ischemic stroke per 476 treated patients while inducing one hemorrhagic stroke for every 1,250 patients. Overall, the total stroke risk was not different. Because of the fact that hemorrhagic strokes typically result in more severe outcomes, the authors advise against the use of vitamin E. It is important to note that the combination of vitamin E with anticoagulant and/or anti-platelet therapy was NOT examined in this trial so that one can not determine how combination therapy might affect the risk of ischemic or hemorrhagic stroke. The review also discusses the conflicting data as to whether vitamin E does or does not alter the risk of coronary artery disease. In general, data to support a reduction in coronary events comes from observational studies while the results from controlled trials fail to support such an effect. The mechanism behind an increased bleeding risk with vitamin E is not yet understood; although a possible anti-platelet effect or an inhibitory effect on the activation of certain clotting factors were mentioned as possible mechanisms. Reference Schurks M, Glynn RJ, Rist PM, Tzourio C, Kurth T. Effects of vitamin E on stroke subtypes: meta-analysis of randomized controlled trials. British Medical Journal 2010; 341:c5702 [or BMJ 2010; 341:c5702 doi: 10.1136/bmj.c5702]	Have questions? Ask ClotCare. Send questions by email to webmaster@clotcare.org. ClotCare is a 501(c)(3) non-profit organization generously supported by your tax-deductible donations and grants from our industry supporters. New Postings: Click here to view full list of new postings
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